Mary E. Brunkow
Mary E. Brunkow | |
|---|---|
| Born | 1961 (age 64–65) Portland, Oregon, U.S. |
| Education | University of Washington (BS) Princeton University (PhD) |
| Known for | FOXP3 |
| Awards | Nobel Prize in Physiology or Medicine (2025) |
| Scientific career | |
| Fields | Immunology Molecular biology |
| Institutions | Institute for Systems Biology Celltech R&D |
| Thesis | Expression and function of the H19 gene in transgenic mice (1991) |
| Doctoral advisor | Shirley M. Tilghman |
Mary E. Brunkow (born 1961)[1] is an American molecular biologist and immunologist. She was known for finding the gene later named FOXP3 as the cause of the scurfy mouse phenotype. This became important to understand regulatory T cell biology.[2][3]
In 2025, she was given the Nobel Prize in Physiology or Medicine for her works in discoveries about peripheral immune tolerance.[4][5]
References
[change | change source]- ↑ "Mary E. Brunkow". The Nobel Prize. Retrieved 6 October 2025.
- ↑ Brunkow, Mary E.; Jeffery, Eric W.; Hjerrild, Kathryn A.; Paeper, Bryan; Clark, Lisa B.; Yasayko, Sue-Ann; Wilkinson, J. Erby; Galas, David; Ziegler, Steven F.; Ramsdell, Fred (2001). "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse". Nature Genetics. 27 (1): 68–73. doi:10.1038/83784. PMID 11138001.
- ↑ "FOXP3 and scurfy: how it all began" (PDF). Nature Reviews Immunology. 14 (5): 343–349. 2014. doi:10.1038/nri3650. PMID 24722479.
- ↑ "The Nobel Prize in medicine goes to 3 scientists for work on peripheral immune tolerance". AP News. October 6, 2025.
- ↑ "Brunkow, Ramsdell and Sakaguchi win 2025 Nobel medicine prize". Reuters. October 6, 2025.
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